Ruiz went on to score another two knockdowns in the seventh before the referee stopped the fight in what was one of the biggest upsets in boxing history.
Former Champion Anthony Joshua and the current WBO, IBF, IBO Heavyweight Champion Andy Ruiz Jr exchanged words on Sky Sport's "Gloves Are Off" and both the boxers expressed their emotions about their upcoming re-match on December 7.
While some prominent boxing voices even called for Joshua to retire there and then, others suggested a tune-up fight would serve him well before getting back in the ring with Ruiz Jr.
"We all have a plan until they hit us, as Mike Tyson would say".
"I have been training and working hard to fight so it's great to get a date and it's very exciting for me to be fighting somewhere different like Saudi Arabia". I'm pretty sure he wants to enclose me. "I am losing eight pounds from what I weighed on June 1".
The only defeat of Ruiz Jr in 34 fights came through a majority decision to Joseph Parker in 2016, a judgment that he still disputes.
But Joshua had no doubt in exercising his rematch clause and - win or lose - will enter the ring many more times afterwards, he insists. "I don't think he likes fighting [against that style]", explained Ruiz Jr.
After landing in the Middle East, Joshua said: "It's going to be an incredible night and I'm thrilled so many of my fans are going to be there, particularly from the UK".
"He saw something that he has never seen before".
"Styles make fights. His style was ideal for me to become the unified heavyweight champion".
"People said before, who would you rather fight with: Joshua, Deontay Wilder or Tyson Fury?"
"I'm just going to keep chasing the world titles", said Whyte, 31.
Punters' faith has been shaken by Joshua's first defeat as a professional, with a relatively generous best price of 4/9 available for a comeback Joshua victory on December 7.