A man in his 80s, not associated with a long-term care home, died, the Middlesex-London Health Unit posted on its daily update.
The UK has recorded 56 more COVID-19 deaths and 4,040 new cases in the latest 24-hour period.
The Middlesex London Health Unit is reporting its second COVID-19 death in less than a week.
Tuesday marks the sixth day of elevated case counts in the region, which spiked over the weekend with a single-day total of 75 cases on Sunday.
The London region now has 6,996 cases, with 6,365 resolved and 187 deaths, leaving 444 active cases. There are now seven staff members who have tested postive for the virus.
There are five additional cases of COVID-19 being reported at area schools, including three in elementary and two in secondary schools.
There are now 17 active cases across 13 schools in Middlesex-London.
Previous outbreaks declared at three Western University residences remain active.
In Elgin and Oxford counties, there were a dozen new infections on Tuesday. The number of ongoing cases is up to 84, with 23 in St. Thomas and 17 in Woodstock.
Toronto had the province's highest daily number of cases with 727, that was followed by Peel with 434, York Region with 229, Durham with 194, Ottawa with 144, and Hamilton with 123.
But hundreds of new confirmed cases were still reported in a day. According to Critical Care Services Ontario, there were 46 people who were admitted into critical care in the last day.
At hospitals in Ontario, the number of COVID-19 positive patients has risen to 1,090.
Ontario has confirmed 51 more cases of the variant first discovered in the United Kingdom, known as B.1.1.7, for a total of 1,800.
There were also 12 further Covid deaths reported in Scotland, which has a death toll that now stands at 7,596. The total number of cases in the nation rose by 411 bringing the total number to 217,890.