"The Republican Party can never again be respected or strong with political "leaders" like Senator Mitch McConnell at its helm", Trump said in a statement. "We want brilliant, strong, thoughtful, and compassionate leadership".
Trump also warned that said he would back Republicans in congressional primaries where "necessary and appropriate", amid reports that McConnell would encourage moderates outside Trump's cuckoo brigade of conspiracy theorists and extremists. The former President routinely insulted his critics and political opponents, as well as members of the military, his own health experts and fellow Republicans who he did not find sufficiently loyal.
"McConnell has no credibility on China because of his family's substantial Chinese business holdings", Mr Trump wrote.
"This is a big moment for our country", Trump wrote, "and we can not let it pass by using third rate "leaders" to dictate our future".
The deeply personal attack follows McConnell's speech over over the weekend saying that Trump was responsible for the deadly insurrection at the Capitol on January 6.
Some, like the seven Republican senators who voted to convict Trump during the second impeachment trial, have sought to distance the party from the former president. I'm more anxious about 2022 than I've ever been.
Mr McConnell's decision to speak to the Wall Street Journal was seen as a move to reassure wealthy donors who have threatened to desert the party as a result of Mr Trump's actions during and in the wake of the Capitol attack. "We don't have a snowball's chance in hell of taking back the majority without Donald Trump. If you don't get that, you're just not looking".
Mr McConnell voted to acquit Mr Trump on the basis, he argued, that the impeachment of a former president was unconstitutional.
He even noted that though Trump is now out of office, he remains subject to the country's criminal and civil laws.
Till now, Trump has not given a clear message about whether or not he would be returning for the presidential elections in 2024. "His behavior during and after the chaos was also unconscionable, from attacking Vice President Mike Pence during the riot to praising the criminals after it ended".
Donald Trump has urged Republican senators to dump Mitch McConnell as their leader in the Senate following his withering criticism of the former U.S. president after his impeachment trial.
In the last weeks of Trump's presidency, the relationship between the then-Senate majority leader and Trump - the two most powerful men in the Republican Party - had essentially collapsed, multiple sources told CNN.
Trump's statement Tuesday adds McConnell to the list of Republicans whom the former President is targeting after they opposed him.
After 50 Democratic senators and seven Republicans voted that Mr Trump was guilty - a majority in the 100-seat Senate, but not the two-thirds needed for a conviction - Mr McConnell let loose, excoriating Mr Trump for the attack that saw five people die and the halls of the USA legislature ransacked by his supporters.
Republican Senate leader Leader Mitch McConnell. McCarthy and Trump discussed the midterm elections in 2022, according to a readout provided by his Save America PAC.