Speaking from the quarters of the Windsor Castle, the queen told the panel that individuals who refused to take the COVID-19 vaccine should "think about other people rather than themselves", marking her very first remarks on the subject.
Now, it is reported the Queen is using her closed family members for support.
"And I think the other thing is that it is obviously hard for people if they've never had a vaccine... but they ought to think about other people rather than themselves".
"It is obviously hard for people if they've never had a vaccine because they ought to think about other people other than themselves", said the Queen, who described Britain's rollout of the vaccination, one of the fastest in the world, as "remarkable".
Edward added: "We've had some brilliant and lovely messages from all sorts of people and we really appreciate that and so does he, I've been passing them on".
"As far as I can make out it was quite harmless".
The Queen spoke with the four Senior Responsible Officers (SROs) overseeing the delivery of the vaccine in England, Scotland, Wales and Northern Ireland to hear about the collaborative effort which has led to more than 18 million people across the United Kingdom getting their first dose of a vaccine.
Nadhim Zahawi, the UK's Covid-19 vaccine deployment minister, said the government rollout was battling a "tsunami" of vaccine misinformation.
Queen Elizabeth joined a group of health officials on a live-streamed conference on Thursday, and encouraged Britons to think about their fellow neighbor before outright refusing to vaccinate against the respiratory disease.
"It's been a rough few weeks for the queen, that's for sure", the source told Us Weekly.
Her comments were described as an "incredibly important vote of confidence" in the campaign.
"Prince Charles, in particular, is making a real effort to step up".
On December 8, Britain became the world's first country to begin a mass vaccination drive against the coronavirus.
The Queen received her first inoculation injection alongside her husband Philip, 99, in January.
The monarch wore the brooch on the day of her engagement to Philip in 1947.
It is understood it is a non-coronavirus health matter.
Earlier in February it was announced other royal family members Prince Charles and his wife Camilla received their first vaccinations. The UK now ranks fifth in the world for having the highest COVID-19 case count and death toll, according to Worldometer.
For the queen, the pandemic has strong similarities to the plague.
Queen Elizabeth recently spoke on a video conference with health professionals organizing the UK's COVID-19 vaccination program in a bid to promote the state's ongoing efforts to curb the spread of the deadly disease.