While church said the patriarch was "without symptoms" and in "excellent" condition, he developed a high fever and his health quickly deteriorated due to chronic heart issues.
Bells on churches throughout Serbia tolled and mourners flocked to light candles as the government proclaimed three days of national mourning.
Serbian Patriarch Irinej, the head of the Serbian Orthodox Church, was admitted to the hospital in Belgrade on 4 November, after was confirmed as having been infected with COVID during a routine test.
At that funeral, thousands of mourners, majority with no masks or keeping any distance between each other, gathered in the Montenegrin capital of Podgorica on November 1, in violation of coronavirus-fighting measures proclaimed by the small Adriatic state's authorities.
Since Amfilohije's death, and the hospitalisation of the patriarch, Serbian priests have been appealing for their parishioners to take the virus seriously.
Serbian President Aleksandar Vucic also attended the burial in Montenegro. They had previously downplayed the threat from the global pandemic and largely ignored bans on large gatherings and preventive measures during prayers and other church services.
"I was honored to know you".
Serbian President Alexsandar Vucic (right) shared a photo of himself and Irinej on Instagram, paying tribute to the religious leader, saying "It was an honour to have known you".
Serbia, with a population of around seven million, has so far reported 110,351 COVID-19 infections, with 1,140 deaths.
He served as the Bishop of Niš from 1975 until January 2010 when he was elected as the 45th Patriarch of the Serbian Orthodox Church after the death of Patriarch Pavle.
Throughout his church reign, he maintained the hardline, anti-Western nationalist stance, criticizing the country's advances to the West and urging instead, closer relations with Russian Federation.
In Orthodox circles, he was considered a moderate, signalling an openness to improving relations with the Catholic Church that have been strained for centuries.
Irinej, a fierce Serb nationalist, often criticised Western policies towards Serbia and urged close relations with Slavic ally Russian Federation.
The predominantly ethnic Albanian territory is home to important SPC monasteries and churches, and Irinej even threatened violence if holy sites were recognised as belongings of the breakaway territory.
Orthodox believers, respecting epidemiological measures, pay their respects to the deceased head of the Serbian Orthodox Church.