The outbreak, which infected 130 people and killed 55, emerged in June, weeks before a separate Ebola epidemic in the east drew to a close.
The official end of the Ebola outbreak follows 42 days since the last patient tested negative and comes six months after a cluster of Ebola cases was detected in Equateur province in the country's north-west. This achievement marks the first time in about two and a half years since DRC was Ebola free.
An outbreak of the deadly Ebola virus disease in Democratic Republic of Congo (DRC) is over, the government announced on Wednesday, after a five-month response supported by the UN's World Health Organization (WHO), and other partners.
"This constituted a major logistical challenge in terms of the implementation of response activities in a health system already weakened by previous epidemics and by a weak involvement of the community", the WHO officials added.
"WHO congratulates responders and all those who tirelessly tracked cases, provided treatment, engaged communities and vaccinated more than 40,000 people at high risk and thanks a wide range of partners for their support", the statement said.
The International Federation of Red Cross and Red Crescent Societies warned that the milestone did not mean the end of the "considerable humanitarian challenges facing the country, including the COVID-19 emergency, along with deep-rooted economic and security issues".
This is the fifth outbreak in Equateur province, he said, adding that epidemic surveillance must be strengthened in the region.
The WHO said it used a new cold chain freezer storage to keep the Ebola vaccine at extremely low temperatures for up to a week, allowing responders to vaccinate people in communities without electricity.
"Tackling one of the world's most unsafe pathogens in isolated and hard-to-reach communities proves what is possible when science and solidarity converge", said Dr Matshidiso Moeti, WHO regional director for Africa. "Tackling Ebola in parallel with COVID-19 has not been easy, but much of the expertise we have built in one disease is transferrable to another and underlines the importance of investing in emergency preparedness and building local capacity".
"The response to the 11th Ebola outbreak had to contend with the COVID-19 pandemic, which strained resources and created difficulties around the movement of experts and supplies".
Jacques Katshishi, secretary general of Congo's Red Cross, said the country's communities must continue to receive support from the worldwide community. This epidemic was the worst in the history of DR Congo, and the second most serious in the world, after the one that devastated West Africa from 2014 to 2016. "This is the time to prepare".