"We need to make this change, this sacrifice, for two weeks", Roussin said. Entertainment facilities with live entertainment must also close, though tasting rooms, which have a separate licence, can remain open.
In addition, restaurants and retail stores will only be allowed to operate at 50% capacity. At restaurants, groups at tables will also be limited to five people and physical distancing must be in place.
Gyms and fitness centres will be required to collect contact information for all attendees.
Venues must reduce the capacity for spectators to 25 per cent of a site's capacity for after-school activities and sporting events.
Manitoba's top doctor said people have "lost their way" when it comes to the battle against COVID-19, as cases and deaths continue to spike in the province.
The new rules come amid climbing daily case numbers in Manitoba, especially in Winnipeg.
The Winnipeg area alone has 1,297 active cases and has a test positivity rate of 5.8 per cent. Roussin said the numbers in the city are concerning.
The province is reporting a record-high 173 new COVID-19 cases, and now has a per-capita active case count that is higher than any other province except Quebec. Winnipeg's is even higher at 6.3%.
Manitoba Health Minister Cameron Friesen said Manitobans need to redouble efforts to follow public health advice. "There was too much high-fiving going on", he said.
All new rules will be enforceable under the law and the province will work to step up enforcement, Roussin said.
The new restrictions will be in effect for a period of two weeks but may be renewed with additional measures if the level of community transmission does not drop in the Winnipeg region.
"We know that we can turn the tide quickly".
"I think this shows that we have a long way to improve to get back to those fundamentals", Roussin said.