Britain's Prime Minister Boris Johnson wears a face mask as he leaves 10 Downing Street to attend Prime Minister's Questions session in Parliament.
He told broadcasters: "I am, I have to say, concerned about what's happening in Manchester where the levels of infection are rising steeply, the level of hospitalisation is rising steeply and we do need to see action".
Talks between Greater Manchester and the Government are ongoing, with the Government urging Greater Manchester to act to protect lives.
On Friday, more data suggested that England was still seeing a sharp rise in cases.
Large parts of Scotland and Wales and the whole of Northern Ireland are also subject to curbs, including closures of pubs and other hospitality venues.
It divides areas into three levels: medium, high, and very high risk levels.
Essex, Elmbridge, Barrow-in-Furness, York, North East Derbyshire, Erewash and Chesterfield will also move into the second tier of measures.
All the changes now mean that millions of people across the United Kingdom are under varying forms of lockdown, as a further 18,980 coronavirus cases and 138 deaths within 28 days of a positive test were reported across the UK.
"Coronavirus is deadly and it is now spreading exponentially in the United Kingdom".
The "rule of six" applies to all gatherings outdoors and people are expected to avoid travelling outside the very-high alert level.
London Mayor Sadiq Khan said there were "no good options" faced with rising cases, hospital admissions and deaths from the virus.
But he said there was "little choice" given persistent issues with the government's contact tracing scheme for people who have tested positive.
Earlier in the week, most of the country was on medium alert in Tier 1, which means subject to the national restrictions now in force, including the rule of six on indoor and outdoor gatherings and 10 pm closing time for pubs, bars and restaurants.
But the changes announced by Mr Hancock on Thursday mean a further 26.7 million people will be covered by the Tier 2 restrictions.
Mr Johnson was criticised earlier this week for ignoring scientific advice for a short lockdown in favour of a targeted local approach. Instead, we're seeing a two-tiered system of tiers emerge.
People in Australia must stay at least 1.5 metres away from others.
If you are experiencing cold or flu symptoms, stay home and arrange a test by calling your doctor or contact the Coronavirus Health Information Hotline on 1800 020 080.