Iranian Supreme Leader Ayatollah Ali Khamenei on Friday rejected USA pressure to participate in nuclear negotiations.
Washington then reimposed crippling sanctions on Iran as part of what it calls a "maximum pressure" campaign.
Some have cited tweets by Iran's Ayatollah Khamenei calling to "eliminate Israel", wondering why they were not similarly labeled. Khamenei was referring to talks between Trump and North Korean leader Kim Jong un.
"Their [The US] short-term goal was to make our people so fed up and exhausted that they would stand up against the (ruling) system", Khamenei said in a televised speech on Friday marking the Muslim religious holiday of Eid al-Adha.
Iran later responded to the US's withdrawal from the deal by slowly abandoning almost every aspect of the agreement, though it still allows United Nations inspectors access to its nuclear sites.
Washington says it wants Teheran to negotiate a wider deal to further curb Iran's nuclear work, halt its missile programme and limit the Islamic Republic's regional influence. The other signatories to the nuclear deal - Germany, France, Britain, China and Russian Federation - have been struggling to keep it alive.
In addition to the US sanctions, Iran's economy has been hit by a fall in oil prices, as well as the coronavirus crisis: Iran has one of the highest death tolls in the Middle East from the pandemic. "The sanctions are apparently against Iran's ruling system, but (in fact) they are against the Iranian people inside".
In addition to the United States sanctions, Iran's economy has been hit by falling oil prices, as well as the coronavirus pandemic - Iran has one of the highest Covid-19 death tolls in the Middle East.
Iran's clerical rulers have tried to prevent a revival of anti-government unrest that have shaken the country in recent years and that began with protests over economic hardship but turned political, with demonstrators demanding top officials step down. A lawmaker said 230 people were killed in the anti-government protests.