By 4:30 p.m., the flames had burned 400 acres, and officials said the fire had the potential to burn 1,000 acres, according to the Los Angeles County Fire Department. No injuries were reported.
The area was expected to have temperatures Thursday in the mid-90s (about 35 Celsius) or higher through the weekend, with low humidity.
To keep track of the fires and for updates, follow the LA County Fire Department, Red Cross LA, Angeles National Forest, and the LA County Sheriff's Department on Twitter.
The fire has quickly spread with fire officials saying that it was roughly 50-acres at 4pm, but within two hours covered about 10,000 with zero containment.
More than 500 firefighters, as well as several helicopters and fixed-wing aircraft, have been deployed to the scene with assistance provided by the L.A. County Fire Department, the Angeles National Forest, and numerous fire departments in the area.
The fire was entirely on federal land as of 6:30 p.m., according to the Los Angeles County Fire Department.
L.A. County Fire Department public information officer Ron Haralson said Thursday afternoon that the fire was moving mostly to the north and northeast and continues to pose a threat to the Lake Hughes and Three Points communities.
According to NBC, there has been mandatory evacuations for at least 100 homes, with reports that the blaze could be seen from up to 65 miles away.
"This is a major fire, we will be here throughout the night", the spokesman said. Evacuation centers have also been organized for small and large animals at the Antelope Valley and Castaic Fairgrounds - you can find the addresses listed here.
The California Highway Patrol set up road closures throughout the area. NBC reporter Mekahlo Medina reported at least four homes destroyed. San Francisquito Canyon Road was closed at Spunky Canyon Road, Pine Canyon Road at Three Points Road and Lake Hughes Road, Three Points Road at Highway 138, Old Ridge Route at Highway 138 and Lake Hughes Road at Ridge Route Road, the CHP reported. The battle is made more hard by rugged terrain and thick vegetation that, in some areas, hasn't burned in several decades.