Spain saw the number of deaths surge to 3,434 after more than 738 people died in the past 24 hours, following Italy in overtaking the figure in China, where the virus originated late a year ago.
The Spanish health ministry said it has registered 738 new coronavirus deaths since Tuesday.
Italy has reported 683 new deaths in the coronavirus pandemic, bringing the total to 7,503 as the confirmed cases rose to 74,386, appearing to level off but not dropping dramatically from previous days.
As the coronavirus continues to hit the health sector with particular force, not only those who work in ICUs, but also those who are at the forefront of patient care, two family doctors are understood to have died from Covid-19, one in a town in Salamanca and the other in Córdoba, becoming the first two doctors to die in Spain from this cause.
The number of coronavirus cases increased by a fifth overnight to 47,610 on Wednesday.
Deputy Prime Minister Carmen Calvo, who has been in hospital since Monday, has tested positive for the virus and is improving, the government said.
More than 447,030 cases of infection have been officially diagnosed in 182 countries and territories since the start of the pandemic.
With hospitals on the brink of collapse, troops have set up a massive field hospital in Madrid's vast IFEMA exhibition center which now has 1,500 beds but which could be expanded to take in up to 5,500 people - making it the largest hospital in Spain.
This is likely to fall on deaf ears when the 27 leaders talk on Thursday - with northern members wary of pooling debt with big spenders - but they will sign off on an "unprecedented" recovery plan.
This comes just a week after President Pedro Sanchez declared a national state of emergency as the country saw the death toll rise.
A tourist wearing a protective respiratory mask walks outside the Coliseum in downtown Rome on 28 February 2020 amid fears of Covid-19 epidemic.
But financial markets rose after USA leaders reached agreement on a stimulus package worth roughly 10 percent of the U.S. economy, an injection Senate Majority Leader Mitch McConnell said represented a "wartime level of investment".