England wicketkeeper Buttler was disciplined by the International Cricket Council for an expletive-laden outburst at Vernon Philander in the tourists win in Cape Town, earning one demerit point and losing 15 per cent of his match fee.
England could well be fighting fire with fire at St George's Park, with the tourists set to unleash their own 90mph-plus man Mark Wood after he appeared to win his battle for selection with Jofra Archer, who has struggled to prove his fitness following problems with his elbow.
He hasn't played in a red-ball match since a Test series in the West Indies last February.
England: 1 Dom Sibley, 2 Zak Crawley, 3 Joe Denly, 4 Joe Root (capt), 5 Ben Stokes, 6 Ollie Pope, 7 Jos Buttler (wk), 8 Sam Curran, 9 Dom Bess, 10 Mark Wood, 11 Stuart Broad.
"That decision hasn't been made", Root told a news conference, with regards to Anderson's replacement.
"We need to find that out and make sure we're really clear going into a five-day game that they are able to stand up to the challenges that will bring, physically and mentally, having not played for a little while".
Root suggested a fully fit Archer would play, but whether his elbow will hold up over five days, allowing him to bowl at his full intensity, is the big question.
"With Jofra, he is 24-years-old, right at the start of his Test career and has a huge amount of ability. It is clear to see what he is capable of doing", Root said.
"But managing workloads is a very important part of it as well". It will be Wood's first game of worldwide cricket since the winning World Cup final back in July.
"The reason we've been quite cautious in terms of rushing him back is that history".
"If he is 100% and firing, the skills he has at his pace will be a great asset in Test cricket".
The four-Test series is locked at 1-1 heading into the third clash.