Toronto remained in front by 18 versus the Spurs, while they additionally had a 14- factor benefit versus the Portland Trail Blazers a couple of days earlier, however ultimately shed the video game (99-101).
Siakam and Powell returned after missing 11 games apiece - Siakam injured his groin on December 18 in Detroit, while Powell injured his shoulder in the same game. DeRozan also collected eight rebounds and four assists while topping 20 points for the 11th straight game.
Lowry finished with 16 points and a season-high 15 assists.
Asked for his thoughts on Lowry's play this season, DeRozan said: "He's been awful". The Spurs reacted with a 17-0 run and took a lead of 88: 87 on Aldridge's chase with 6:34 in the lead. Toronto took a one-point lead on Siakam's free throw but Belinelli hit a three-pointer with 28.8 seconds to play for the Spurs.
When the Spurs visited Toronto in February previous year, DeRozan turned the ball in the last few seconds and led to Kawhi Leonard.
"I think every man on that team will tell you that they received a text from me as soon as they got on their phone, congratulated them and were happy for them". Leonard sealed the victory on a pair of free throws in the final second as the crowd chanted "M-V-P!" It's a chance players in this competition don't get, and to be connected with those guys and with this country to see them do that, I was absolutely happy for them.
"He has been bad", DeRozan joked with a knowing grin when asked about Lowry's game. It seems like the older he gets the better he still gets.
Welcoming the two back into the lineup should provide a big boost for this Raptors team. His three-pointer put the Raptors up by 12 midway through the quarter.
"I feel like I kind of lost my rhythm a little bit", Siakam said on his second half. "Definitely a bit exhausted, but I'll take that if I'm not there for a month".
The Raptors head to Oklahoma City on Wednesday then return home to host Washington on Friday.