Whether it be a brisk stroll all the scheme during the park or high depth practising on the gymnasium, train does a body ethical. But, what if you could reap the rewards of a good workout without even lifting a finger?
Sestrin protein can mimic the effects of a really good workout in flies and mice, and the findings from this new study can possibly help researchers deal with muscle wasting that occurs due to ageing or other scenarios.
Taking advantage of Drosophila flies' normal instinct to climb up and out of a test tube, their collaborators Robert Wessells, Ph.D. and Alyson Sujkowski of Wayne State University in Detroit developed a type of fly treadmill.
The protein is called Sestrin and a study performed on mice and flies found that administering it resulted in them burning fat and gaining muscle even without exercise.
When they compared the results from both fly batches, they found that the normal flies' ability to run around improved over a period by four to six hours, while the flies without Sestrin did not make any progress without exercise. Their first step became to back a bunch of flies to determine.
Myungjin Kim, an associate professor at the Department of Molecular and Integrative Physiology, said researchers had previously observed that Sestrin accumulates in muscle after exercise.
The team wanted to know more about the protein's apparent link to exercise. Scientists from the University of MI therefore wanted to see if artificially upping an animal's Sestrin levels could produce the beneficial effects that are associated with the protein.
When the team maxed out the levels of Sestrin in the muscles of normal flies, they found that those flies had the abilities above and beyond the trained flies, without doing any exercise. Without needing to exercise, these flies displayed significantly higher performance levels than regular flies, again indicating that Sestrin in some way enhances physical capacities.
This "underlines that sestrin alone is enough to bring many benefits from exercise and movement", said Lee.
"We propose that Sestrin can coordinate these biological actions by turning on or off varied metabolic pathways", says Lee. "This type of combined effect is important to get the effect of the training". Not quite, said Lee, adding that Sestrins are not small molecules, but "we are working to find small molecule modulators of Sestrin".
The scientists are now further exploring the manner in which Sestrin is produced within the body, and are looking into the development of supplements containing the protein.
Sestrin molecules are at the moment too huge to be made right into a complement, the specialists stated, so their work is ongoing. "This is very critical for future study and could lead to a treatment for people who cannot exercise".