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Prince Harry, Duke of Sussex, and Meghan Markle, Duchess of Sussex, will miss the event while the President and First Lady Melania Trump visit for the North Atlantic Treaty Organisation summit, which is being held outside London in Watford.
'It be a considerable time of year to serve those round you who would be less fortunate, or who would adore even the smallest act of kindness.
"We have selected twelve organisations caring for those in need - especially at this time of year", the message continued.
"There are, thankfully, so many organisations around the world doing good on global and grassroots levels, many of which are not on Instagram".
"We would love to hear about the ones that inspire you - so please tell us and add your country's flag!"
This isn't the first time Meghan has missed out on a Trump visit, she was also absent from his June trip since she had just given birth to baby Archie.
Nevertheless, diversified stories claimed that the family could perchance also simply occupy spent Thanksgiving within the United Kingdom, with Meghan volunteering at a homeless refuge come her Windsor dwelling.
Homelessness charities Refuge, the Salvation Military and the Los Angeles Mission were all integrated within the list.
Harry and Meghan's seasonal plans were revealed on Twitter, and it is said they are "inline with precedent set" by other family members - including Harry's brother Prince William and his wife Catherine, Duchess of Cambridge - who have also skipped the Sandringham festivities in the past.
The Sussexes' decision not to join the royal family has fuelled ongoing rumours of a rift with Prince William and Kate.
While the Duke of Sussex remains an active member of the Royal Family through his commitment to charity, the Norwegian princess was stripped of her Her Royal Highness style shortly before her marriage in 2002 to allow her more freedom as she launched her personal business.
On Friday, Meghan and Harry wished their followers on Instagram a Happy Thanksgiving.