"The trans-continental storm system that has hammered the western USA andnorthern Plains with heavy snow and strong winds has now reached the GreatLakes region", the National Weather Service said in a bulletin on Sunday.
Also in South Dakota, a small-engine plane carrying 12 people crashed, killing nine aboard and leaving three others injured.
Airlines have delayed flights across the country on what is expected to be the busiest travel day in the US.
Families returning home on Sunday from their Thanksgiving weekend may have some issues with their travel plans.
Flight-tracking site FlightAware said airports at San Francisco and Newark were among the worst affected.
He said weather would be among several factors reviewed by NTSB investigators, and inclement weather was making travel to the crash site hard.
About 50 million in the United States are under some kind of winter weather alert. The storm then moved slowly eastward across the Plains and upper Midwest areas between November 27-30, spreading snow and strong winds through parts of those regions.
Boston is projected to get between 3 and 6 inches of snow.
Forecasters said a new storm is expected to bring California several metres of mountain snow, rain and gusty winds through the weekend.
The city of Duluth, Minnesota, was blanketed with 21.7 inches (0.6 meters) of snow as of 12 p.m. Sunday.
Downed tree limbs and power outages are possible.
The storm has hammered parts of the country for days over the Thanksgiving period, dumping heavy snow from parts of California to the northern Midwest and inundating other areas with rain. Gov. Andrew Cuomo has placed the National Guard on standby, he said.
Farther south, precipitation was in the form of rain and thunderstorms.
"A cold front will be positioned from central OH, arcing eastward near the Appalachians, then south-southwestward into the Florida Panhandle", it said.
Much of interior MA, meanwhile, could get up to a foot of snow.
Wind gusts could reach up to 45 miles per hour in Tennessee and 50 miles per hour in North Carolina, the NWS says. That could cut down on snowfall totals but is making roads treacherous. The weather service warned of an icing threat starting Sunday afternoon and continuing through much of Monday.
Shasta County is located between Sacramento and the OR border.
The Sierra Nevada could receive also receive snow, according to the Weather Channel.
"No Wi-Fi, no electricity, so it's like we're back in the 1800s", Fabrice Vignati who was in Crestline - about 70 miles east of Los Angeles - told CNN affiliate KTLA.
The city's Department of Sanitation has 705 salt spreaders ready to begin work once two inches of snow has fallen, officials said.
The storm will linger over the state through Tuesday, the weather service said. But flights are also packed - AAA said about 4.5 million Americans were expected to fly during the Thanksgiving holiday this year. A record 31.6 million passengers were forecast to travel on U.S. airlines during the Thanksgiving holiday period, up 3.7% from a year ago.
Due to delays and cancellations, Delta Airlines announced weather waivers for almost two dozen cities in the Northeast for Sunday and Monday, including airports in Boston and the NY area.