He exited with almost five minutes left in the third quarter and the Bucks ahead 93-54.
The only Antetokounmpo playing in the fourth quarter was Giannis' older brother Thanasis, who drew cheers from the crowd when he slipped in for a layup early in the period.
Giannis Antetokounmpo resumed regular double-double service as he racked up 29 points and 15 rebounds in just 22 minutes of action, while Khris Middleton starred on his return to the starting lineup, and the bench unit got plenty of opportunity to showcase their abilities too.
"I know we're playing great basketball, everybody's having fun but that's in the past", Antetokounmpo said.
Julius Randle paced NY with 19 points and Damyean Dotson had 15. The Knicks shot 30.8% from the field (28 of 91) and made 25.6% of their 3-point tries (10 of 39).
Knicks: Point guard Frank Ntilikina was out after injuring his back in New York's 113-104 loss to Boston on Sunday at Madison Square Garden. Veteran forward Marcus Morris (cervical spasms) missed his second consecutive game.
Knicks coach David Fizdale admitted his team had been bracing for an onslaught from the tip-off.
The Jazz had trailed by 19 points after three quarters and managed to claw back the deficit to seven points with one minute remaining before the Sixers steadied the ship for the win. "Giving him a couple games is going to be really wise in the long run", Budenholzer said. "Giannis has been a creator since back when Jason (Kidd) was coaching".
In November, the Bucks played 16 games and won 15 of them, outscoring their opponents by 209 points - 1,928 to 1,719. He's an unselfish player; he's always been a player who likes to get his teammates involved.
Knicks: Host the Denver Nuggets on Thursday (Friday, PHL time). It was just the 13th time in franchise history Milwaukee has beaten a team by 40 or more points.