No player bears the brunt of that bad blood more than Raheem Sterling on his return to Anfield.
"He has had a long career at the top, won the Copa America".
Two years later, he left in acrimonious circumstances with Liverpool going backwards on the field and disputes over his contract off it.
The two teams played out a 0-0 draw at Anfield last season, as both teams appeared to cancel each other out.
The England worldwide is one of many tales of what might have been for Liverpool over the past three decades, but is also symbolic of how times have changed at Anfield.
"It is still very, very early in the season and the league is just as competitive". However, they are very suspicious of the news of Ederson given by Pep Guardiola. It was a rotten game of football last time, but this is what tension does to the best of teams - City can not afford to lose it.
"When it happened to Sean it was probably the lowest point for me in my whole time at Liverpool because that is something that should not happen in life and it should not happen around a football game", said the manager.
Sterling can not be faulted for a sloppier start to the season by Guardiola's men after two near-perfect campaigns.
Fortunately for City, Bravo's suspension will only apply to European matches, leaving him free to line up against Liverpool, but there may be some concern over his mental sharpness.
"The police knew it for the Champions League game and didn't do anything", he said. "His physicality is incredible". He is an exceptional goalkeeper and has played a lot of games for Chile.
"We had great sides in 1993, 94, 99 and 2008".
City are concerned their team bus could come under attack from Liverpool fans just like it did in 2018 before the Champions League quarter-final.
Liverpool's Virgil van Dijk and Dejan Lovren in action with Manchester City's Sergio Aguero in this file pic dated Jan 3, during the match at the Etihad Stadium, Manchester.
Ferdinand believes Mane could punish City's patchwork defence.
Such is Liverpool's rampant form at the moment, Ferdinand even goes as far to say the Merseyside club are ready to "dominate" the league for an extended period, sitting a cut above the rest right now. There is not one where anyone said "You can lose that". "He is among the five best attacking players in the world, definitely".
Jurgen Klopp has called on everyone associated with Liverpool, from supporters to the hot dog sellers, to get fully behind their side in Sunday's showdown with Manchester City.