On October 7, 2002, a 17-year-old winger named Cristiano Ronaldo scored his first two goals as Sporting CP beat Sporting Moreirense 3-0 and now, 6,213 days later, he scored his 700th as Portugal beat Luxembourg by that same scoreline.
Portugal remain second in Group B, five points behind Ukraine, but four points clear of Serbia in third.
"In the first 25 minutes we were very good, very dynamic and created chances", said Fernando Santos who was marking his fifth anniversary as Portugal coach. "After the break, we started well and I think we quickly controlled the game, but after the second goal, the players started thinking ahead to Ukraine".
Silva gave Portugal the flawless start when he opened the scoring on 16 minutes when he controlled and fired home from close range.
Barcelona defender Nelson Semedo's effort was only parried by Luxembourg goalkeeper Anthony Moris and Manchester City midfielder Silva was on hand to sweep in the opener. Retired striker Pauleta is second on the list, scoring 47 goals for Portugal.
The 65th minute strike increased his tally to 699 goals after 972 matches in all competitions for club and country.
Goncalo Guedes wrapped up the win a minute from time, but Ukraine's 2-0 success over Lithuania ensured they retained their cushion at the top of the group.
Ronaldo and Lionel Messi are regarded as the best footballers in the past ten years and the Portuguese will want to get 700 career goals before his greatest rival.