Across the United Kingdom, boys will receive their first dose aged 12 to 13 - year eight for those in England and Wales - with a follow-up dose six months to two years later, also given in school.
HPV is a sexually transmitted virus linked to more than 99% of cervical cancers, as well as 90% of anal cancers, about 70% of vaginal and vulvar cancers and more than 60% of penile cancers.
Some 100,000 cases of cancer could be prevented in Britain in the next 40 years by a vaccine against the human papillomavirus (HPV) that causes cancers of the cervix, mouth, anus and genitals, United Kingdom health officials said on Tuesday.
To date 10 million doses of HPV vaccine have been given to young women in Britain, meaning that more than eight out of ten women aged 15 to 24 have been vaccinated.
The vaccine is a mimic of the virus particle, but when administered into someone's muscle, it creates many more antibodies than a natural infection would, according to John Doorbar, professor of viral pathogenesis at the University of Cambridge.
Since the jab was introduced, infections of some types of HPV in 16-21 year old women have reduced by 86% in England.
More than 3,000 women in the United Kingdom are newly diagnosed with cervical cancer each year in the United Kingdom and the disease kills over 850 women annually.
The additional injections will lead to the prevention of more than 64,000 cervical cancers and almost 50,000 non-cervical cancers by 2058. That would include some 30,000 cancer cases in males.
Dr Mary Ramsay, head of immunisation at Public Health England (PHE), encouraged parents of all eligible children to "take up the offer for this potentially life-saving vaccine" without delay.
"It has been so successful for girls and lots have been protected and we are protecting even more people by immunising boys too".
Professor Helen Stokes-Lampard, chairwoman of the Royal College of Global Positioning System, said: "The potential of this vaccine to save lives and prevent the complications of cancer is huge, and since it has been available on the NHS for girls, it has had excellent take-up, with impressive results - it's important this success is replicated with boys".
The USA is one of the few other countries to offer the vaccine to boys. Last month the US Centers for Disease Control and Prevention's Advisory Committee on Immunization Practices, known as ACIP, voted unanimously to recommend HPV vaccines for both boys and girls and men and women until age 26.
"The government now needs to work with the NHS and local authorities to ensure that we maintain efforts to actively communicate the important health benefits of this vaccine to parents and adolescents".
Boys in schools across Kent will soon be offered the free Human Papilloma Virus (HPV) vaccine for the first time.