It was in the 2009 Club World Cup final when he scored a victor to give Barcelona the trophy. When you've got someone who comes in and puts their arm around you and puts to bed the situation before, you can't be letting them down and, more importantly, you can't be letting your team-mates down.
However, Fred suffered the humiliation of being nutmegged by Lionel Messi in the lead-up to FC Barcelona's first goal at Camp Nou. I think the vast majority know what future they will have - for good or bad.
Former Manchester United defender Ferdinand was critical of Fred's role in Messi's breakthrough goal that ended the visitors' resistance.
Ferdinand added: "We said before the game that if he decides to turn up and take the game by the scruff of the neck then he can do it and he's done that".
The 44-year-old tore into several United players after a performance that he clearly felt wasn't good enough from a United team.
"Liverpool's front three will cause massive problems so I think it's a 50-50 tie that semi-final".
"I thought he was really poor tonight, rolling his foot over the ball all the time, playing for himself, not popping it off and moving, didn't look interested at times - but he's a great player, and can be a great player, he just needs to get that focus back".
David De Gea made a rare mistake for Messi's second goal minutes later to effectively end Manchester United's hopes of an unlikely comeback.
The last time the Premier League trophy was lifted at Old Trafford was back in 2013 and Souness said: 'There is no quick fix at Manchester United'. (Marcus) Rashford is up and coming, but is he the real deal?
"You see [Scott] McTominay in midfield, it's a big lesson for him over two games - he's done well in the games". I certainly wouldn't, even though people will expect me to say that.
Watch Neville's post-match reaction in full here.