The rivalry has not dampened down over the years, not least given the infamous game in 2014 when Steven Gerrard slipped against Chelsea to allow Demba Ba to score.
Liverpool will be desperate to avoid a repeat, while Chelsea will want to once again scupper their rivals hopes of a first league title in 29 years.
"It's a must-win for Liverpool".
However, Maurizio Sarri's side have a poor record this season away from home against the top six in the Premier League, losing their last five.
"Manchester United is there, Spurs is there, Arsenal, despite their last defeat, are also there". But it will be up to the likes of Mo Salah, Roberto Firmino and Sadio Mane to break down Chelsea's backline and secure a massive three points to stay alive for the title. And to add something more to the game, the last time Liverpool were nearly winning the title it was Chelsea who spoiled the celebration at Anfield. "For me that's the big game of the weekend".
Despite my suggestion that City are looking vulnerable, I'd still expect them to find a way to win today and then all eyes will switch to Anfield for a game that could be billed as Liverpool v Hazard.
An interesting little facet of this game is that it will come minutes after the end of Manchester City's match at Crystal Palace.
Joel Matip has shown admirable form alongside Virgil van Dijk and that is most likely to be the partnership the Reds will go with as they pursue the Premier League and Champions League.
Every team going for four trophies in the same season have slipped up at some stage of their journey and while City have a big chance of turning their tie against a Tottenham side deprived of the services of Harry Kane, they don't look as assured as they did a few weeks back.