With four English clubs reaching the quarterfinals for the first time since the 2008-09 season, we may be on the cusp of a new period of European domination by the richest league in the world.
Last season's beaten finalists booked their spot in Friday's draw, while Premier League rivals Manchester City had put themselves in the hat by annihilating Germans Schalke on Tuesday, and last week Tottenham finished the job against Borussia Dortmund as Man United stunned PSG.
"The calendar for the semi-finals (including a potential reversal involving Manchester United FC, for the same reasons, if both clubs from Manchester are still remaining in the competition) will be communicated to all parties on 18 April 2019, following the return legs of the quarter-finals".
"With the others, Juventus can play on equal terms".
Below we take a look at how each of the aforementioned quadruple have fared at the quarter-final stage in the Champions League era (1992/93 onwards).
Former Blaugrana coach Pep Guardiola's team are one of the favourites to win the title and Manchester City have the quality between the four lines, as well as on the bench, to reach the Estadio Wanda Metropolitano final.
Spurs were one of Barcelona's opponents in the group stages and Ernesto Valverde's side came out undefeated in the games against the Premier League team, after prevailing at Wembley 4-2 and drawing 1-1 at the Camp Nou.
"They deserve to be there and we know they will be tough teams". He helped Real win four of the past five Champions Leagues and it is hard to imagine the Spanish giants winning any of them without the Portuguese star's contribution. The same applies to Messi, who has not been eliminated from the competition by an English team since Chelsea beat Barcelona in the semifinals en route to their win in 2012.
The last time Juventus faced Barcelona was in 2017/18 and the Italian side knocked out the Catalans, as a 3-0 victory in Turin was followed by a 0-0 draw at the Camp Nou.
"Man City kind of got through pretty comfortably in the end".
Everything inevitably comes to an end at some point but if an English team is to win the Champions League this season, they are likely to have to beat a team containing Messi or Ronaldo, or defeat both, in order to claim the trophy.