Willy Caballero may replace Kepa Arrizabalaga in goal with the tie all-but won, especially considering Chelsea's recent hectic fixture list.
Chelsea, who won last week's first leg game in London 3-0, trained at the stadium on Wednesday.
Mateo Kovacic should sit in front of the back four while N'Golo Kante is likely to start alongside the Croatian with Ross Barkley one booking away from a suspension.
One man the Chelsea manager will have to do without is Argentina global Gonzalo Higuain, who has been left behind in London.
And Sarri explained why his main attacking outlet has not travelled with the rest of his squad.
'He had a fever after the league match for two days. "Yesterday in the evening with the doctor we made a decision to leave him at home in order to recover him for the next match".
Meanwhile, Hudson-Odoi will hope to start at the expense of Pedro on the opposite wing while Ruben Loftus-Cheek is in contention for a midfield berth.
'I have a lot of players of course.
"I don't know the reason - probably the winter".
"I don't know the reason, probably winter, because I played here two years ago and the pitch was wonderful [but it is now] very, very risky".
Sarri added,"I want to send to my team the message the match is very important".
Hudson-Odoi got a second-half appearance in the draw against Wolverhampton Wanderers at the weekend and every fan is willing him on when he's on the ball.
With Higuain absent, Olivier Giroud should start upfront.