"It is true that scoring an away goal is important because if you don't, it leaves everything up in the air for the second leg".
The Spanish champions won the domestic double last season in Ernesto Valverde's first campaign as coach at the Camp Nou, but that achievement was marred by the nature of their exit from Europe.
Barca's last away win in the competition's knockout stage came in 2016 against Arsenal but Valverde continued: "Records are there to be broken".
"It shows that it is a hard competition, but challenges are there to be overcome", said Valverde at a press conference at Lyon's Groupama Stadium on Monday.
"When we came into that match, I remember everyone telling us they were the best opponents for us, that they were the weakest side, but that did not help us".
Messi was again the match victor, as they beat Real Valladolid 1-0 on Saturday, to open a nine-point gap ahead of rivals Real Madrid.
"We need to come into these games not with our guard down but with our guard up".
"It was also said that we did not score away from home and this year we have done so in big (group-stage) games against Tottenham and Inter".
With players like Tanguay Ndombele, Nabil Fekir, Memphis Depay in midfield and Moussa Dembele in attack, Lyon boast plenty of quality and Busquets insists Barca will be wary.
"I am not going to deny that he can be a decisive player for them".
Here, Sports Mole has taken a look at how Barcelona could line up in France on Tuesday night.
"A completely different scenario to the group stage".
"They demonstrated this season - winning against City and PSG - that we will have to be very attentive and not think that the game will be easy".