Guardiola said he was happy with his squad, with City challenging for silverware in four competitions.
"We realised [how good they were] when we played them in the EFL Cup last season and again early this season", the former Barcelona boss told a pre-match news conference, having overseen a penalty shoot-out triumph in the former game before his team were held 1-1 at Molineux in August.
He said: "Sometimes we have done it but normally when you want to buy one player it is for the next five or six years and normally it doesn't happen in this window".
De Bruyne went straight down the tunnel, and sat in the dressing room, rather than watch the rest of the game on the substitutes bench with his team-mates.
"The big clubs don't buy important players for just six months". "He's a little bit better, yesterday was his first training session".
Guardiola hopes to have the Argentine back for the game against Wolves on Monday, with Vincent Kompany keen to prove his fitness too.
"Sergio after Liverpool was sick", Guardiola added.
Guardiola is unsure whether the Premier League champions can wedge in a trip given their hectic schedule. I hope they will be ready'.
"Vincent is recovering also well after the game with Liverpool".
The manager said City would do everything they can to help Gabriel Jesus after close relatives including his mother, Vera Lucia Diniz de Jesus, returned to Brazil.
Guardiola did take his players to Abu Dhabi last March, after their surprise FA Cup fifth round defeat at Wigan left them with a free week. We are there to help. But of course, we cannot substitute the mother and when the family can't be here, it's hard. "But it is what it is and he has to handle that situation". He's not alone, he has friends, a special connection with the Brazilian players. "I think it won't be a problem for the next months".