Between 1999 and 2015, Uterine cancer rates rose by 12 percent, from about 24 cases per 100,000 women in 1999 to 27 cases per 100,000 women in 2015, according to a new report from the Centers for Disease Control and Prevention.
"Our findings are consistent with prior studies indicating that black women with hormone-receptor positive, HER2-negative breast cancer have worse prognoses than women of other racial and ethnic backgrounds, even when they have access to the same contemporary cancer care", said Kathy Albain, MD, Huizenga Family Endowed Chair in Oncology Research and professor of medicine at Loyola University Chicago Stritch School of Medicine and director of the Breast and Thoracic Oncology Programs at the Cardinal Bernardin Cancer Center of Loyola Medicine in Maywood, Illinois.
"There's no doubt that the incidence and mortality of uterine cancer, specifically endometrial cancer, is higher in African-American women. Indeed, almost half of individuals in this study who had the highest amounts of trunk fat had BMIs within the lower quartiles", Iyengar and co-authors wrote.
Black women with breast cancer have worse clinical outcomes even when 21-gene recurrence scores (RS) are similar, according to a study presented at the annual San Antonio Breast Cancer Symposium, held from December 4 to 8 in Texas. The analysis included 3,460 postmenopausal women ages 50-79 with BMIs in the range of 18.5 to 34.9.
Of these, 3460 participants underwent body fat measurement with dual-energy X-ray absorptiometry (DXA) at three USA designated centres with follow-up.
"The corresponding adjusted hazard ratios for ER-positive breast cancer were 2.21 (95% CI, 1.23-3.67) and 1.98 (95% CI, 1.18-3.31), respectively".
Increased risk for invasive breast cancer was associated with every continuous five-unit increase in whole-body fat (HR 1.35, 95% CI 1.14-1.60), percentage of whole-body fat (HR 1.27, 95% CI 1.08-1.48), and trunk fat mass (HR 1.56, 95% CI 1.18-2.06), the study found. Similar positive associations were observed for serial DXA measurements in time-dependent covariate analyses.
In addition, the investigators found higher circulating levels of insulin, C-reactive protein, interleukin-6, leptin, and triglycerides, and lower levels of high-density lipoprotein cholesterol and sex hormone-binding globulin in women with the highest trunk fat mass. Insulin resistance, breast adipose inflammation, and elevated leptin levels have all been thought to play a role in the pathogenesis of obesity-related breast cancer, the researchers explained.
"Our results suggest that biological differences may contribute to the significantly different outcomes of black women compared to others with breast cancer", Albain said in a statement.
The study was funded by the Breast Cancer Research Foundation.
Pimentel and co-authors reported no conflicts of interest.