The Vatican said the pope had accepted an invitation from Sheikh Mohammed bin Zayed al-Nahyan, Crown Prince of Abu Dhabi, and the tiny Catholic community there.
Dubai's leader said the visit "will strengthen our ties and understanding of each other, enhance interfaith dialogue and help us to work together to maintain and build peace among the nations of the world".
Greg Burke, the Director of the Holy See Press Office, said on Thursday that the visit highlights Pope Francis' commitment to building a culture of encounter.
Hinder, whose jurisdiction includes the United Arab Emirates, Oman and Yemen, said the Mass would be held on February 5.
The theme of the UAE trip is peace, with the logo featuring a dove carrying an olive branch.
Francis, who turns 82 this month, will make the trip just a week after returning home from Panama, where he is due to visit January 22-27 to participate in the Catholic Church's World Youth Day rally.
The UAE trip will come ahead of a visit in March to Morocco.
As early as 2016, there had been talk of Pope Francis' visit to the UAE following an invitation by its then-Minister for Tolerance Sheikha Lubna Al Qasimi in June of that year.
The Emirati crown prince also held talks with the pope's top diplomat, Cardinal Pietro Parolin, in September 2016.
The freedom to practice Christianity - or any religion other than Islam - is not always a given in the Gulf and varies from country to country.
Many of the Catholics are workers from Africa, Bangladesh, India, Pakistan and the Philippines, though some are locals.
"It has been the hope of all Catholics in the UAE that the Holy Father would visit us here", Father Ani Xavier, parish priest of St Paul's Church in Mussaffah, told The National Dec. 6. Saudi Arabia, however, prohibits the establishment of a church there.
Almost 80 per cent of the population of the UAE is Muslim, while Christians constitute around nine per cent, according to the Catholic News Agency.