Doctors believe the procedure could help infertile women whose only options now are surrogacy or adoption.
A woman who was transplanted with a deceased donor's womb has given birth to a baby girl, researchers in Brazil say. Text the word "Farmers" to 22071. Babies have been born after womb transplants from live donors, typically from a relative, but using organs from dead donors could widen the...
Uterine transplants from deceased donors have been attempted previously, but until last December no recipient had carried a child to term. Though there have been 10 uterus transplants from deceased donors in the United States, the Czech Republic and in Turkey, this is the first to result in a child. The first of these occurred in Sweden in 2013 and since then, 11 babies have been born after similar procedures, according to the Lancet. However, a woman who received a live uterine transplant gave birth to a baby boy in 2017, making it a first for the U.S.
Experts estimate that infertility affects around 10 to 15 per cent of couples of reproductive age worldwide.
"The first uterus transplants from live donors were a medical milestone, creating the possibility of childbirth for many infertile women".
The current norm for receiving a womb transplant is that the organ would come from a live family member willing to donate it.
The uterus transplant, in this case, happened in September 2016.
The recipient of the uterus was a 32-year-old woman born without a uterus as a result of Mayer-Rokitansky-Kuster-Hauser (MRKH) syndrome. The unnamed uterus recipient was a 32-year-old woman born without a uterus, but otherwise healthy.
In a surgery lasting 10.5 hours, the uterus was removed from the donor and transplanted into the recipient, where it was connected to the recipient's veins and arteries as well as her ligaments and vaginal canals.
These are still early days for uterine transplants, says Kate O'Neill, co-lead investigator for the University of Pennsylvania's uterus transplant program, who was not part of the work in Brazil.
She was given five immuno-suppressant drugs -which she took throughout her pregnancy - antibiotics and anti-blood clotting treatment.
No. In order to keep the uterus after birth, the mother would have to continue taking immune system suppression medications which can pose risks. Falcone said the fact that the transplant was successful after the uterus was preserved in ice for almost eight hours demonstrated how resilient the uterus is. Doctors were able to remove eggs, fertilise them with the father-to-be's sperm and freeze them.
Ultrasound scans at 12 and 20 weeks revealed no foetal anomalies.
The woman was given immunosuppressants to prevent rejection of the womb, while the team took biopsies of the cervix at regular intervals to check for signs of rejection. The immunosuppressive therapy was suspended at the end of the hysterectomy. When the researchers wrote the paper describing the case - about seven months after the birth - both mom and the baby girl were healthy.
"It enables use of a much wider potential donor population, applies lower costs and avoids live donors' surgical risks".