Around 70 girls were invited to join the Arsenal stars in London's Tape club, as the party racked up a bill of nearly £30,000.
Arsenal says the club will talk to the players who were recorded apparently inhaling nitrous oxide in a London nightclub.
Arsenal have released a statement revealing that they will "remind players of their responsibilities" after several of them were videoed appearing to inhale laughing gas.
The club has now responded to the shocking footage, with a spokesperson telling the BBC that the players would be "spoken to and reminded of their responsibilities".
Premier League top scorer Pierre Emerick Aubameyang is said to feature in the video
The footage is the latest in a series of incidents of top players being linked with nitrous oxide, with Raheem Sterling being warned by Liverpool after footage emerged of him using the substance in 2015.
Pierre-Emerick Aubameyang's arrival in January appeared to jeopardise his Arsenal career before it had even truly begun, but the pair have dovetailed superbly in Unai Emery's new-look side.
On the football front, the Gunners are unbeaten in 20 matches across all competitions.