To achieve this, Mr Hancock will encourage people to take more responsibility for their own health.
"In the United Kingdom, we are spending £97 billion of public money on treating disease and only £8 billion preventing it across the UK".
"But Matt Hancock must realise his plans will start at a disadvantage as local authorities struggle with planned cuts to public health budgets of nearly four per cent per year until 2021".
"But we have a responsibility to pay our taxes to fund it and to use the health service carefully, with consideration for others, and to comply with medical advice to look after ourselves".
He said that cuts to services like smoking cessation and sexual health have directly contributed to "unacceptable variations" quality and quantity available to patients in some areas.
He said: "Preventing illness and disease is huge area with enormous potential - much of it extending well beyond the NHS". "The government has a duty to deliver on this".
Mr Hancock later told Sky News the recent £20.5bn extra funding for the NHS was not reliant on a Brexit deal.
His plans include increasing specialist mental health services to a further 30,000 women during and post pregnancy by 2020 to 2021, halving childhood obesity, diagnosing 75% of cancers at stages 1 and 2 by 2028, and offering whole-genome sequencing to all seriously ill children and those with cancer by 2019.
Focusing on prevention will help to tackle health inequality, Mr Hancock is expected to tell the meeting today.
Health Secretary Matt Hancock says that employers need to do more to "check in on" sick workers. "That's why we need a new 21st century focus on prevention".
This has prompted Helen Donovan, from the Royal College of Nursing, to warn promises needed to be backed up with serious investments at a local level, while Labour's Jonathan Ashworth says while the plans were "laudable", "unless ministers reverse these cuts and start fully funding public health services, these announcements will be dismissed as a litany of hollow promises".
There's also a strong emphasis on people taking responsibility after their own health and receiving care in the community rather than hospital, all in the hope of "slowing the growth in demands on the NHS and making it sustainable for future generations", says the document, "whilst closing the gap between the richest and poorest". "Having proper post diagnostic support in place helps not only these people, but also benefits the NHS which is languishing in a time of reduced resources and a lack of understanding around life-limiting conditions, especially in the case of dementia".