The Massachusetts State Athletic Commission denied his license application on Tuesday, however, because Saunders tested positive for oxilofrine, a banned stimulant, in a test administered August 30 by the Voluntary Anti-Doping Association.
"Boo Boo" Andrade (25-0 16KOs) must reset his radar from training for the tricky southpaw Saunders to the big-hitting African, and Kautondokwa has inspiration close to home in his camp for his first World title fight.
Warren spoke to talkSPORT on Thursday regarding Saunders situation: "The Massachusetts State Athletic Commission, whose jurisdiction the fight takes place under, at their hearing yesterday they had said they had grounds for denial of his application for a license".
WBO president Francisco Valcarcel Mulero confirmed Andrade's bout with Kautondokwa will be for the now-vacant title, while also calling for the governing body to hand Saunders a six-month suspension.
WBO middleweight champion Saunders was notified two weeks ago that he had failed a drug test.
Billy Joe Saunders underwent testing by both WADA and VADA.
"They referred to a prohibited list which is published by the World Anti-Doping Agency (WADA) and they applied that to deny him a licence. He needs a recommendation from the British Boxing Board of Control [to have the suspension lifted], and if he does all that, we are willing to put him back in the rankings after his suspension". VADA prohibits it at all times. All that VADA do is conduct a test and report the results. The substance they found in their test is prohibited by them, but under WADA it is allowed out of competition, which is set up until the day before the fight.
The Englishman had been due to defend the belt on October 20 against Demetrius Andrade, who will now face Walter Kautondokwa instead in Boston. "Further, the MSAC refused to properly consider submissions from Billy Joe's representative despite him being present at the hearing".
Warren said: 'I have read comments that MSAC had no choice as a failed test is a failed test however these comments are, with respect, misleading and ignorant of the fact the MSAC apply the WADA code.
"VADA bans everything. They are not recognised in Great Britian, they are not recognised by UK Anti-Doping and they are not recognised by the British Boxing Board of Control".
Kautondokwa (17-0 16KOs), who has replaced Billy Joe Saunders in the middleweight bout, is confident that he can add to his formidable knockout record in MA.