She's five feet tall, 100 pounds, has green eyes, and blond or strawberry colored hair. She is not considered to be a suspect in her parents' deaths at this time, Fitzgerald said.
"Right now she's "missing and endangered" - she's not listed as a suspect", Fitzgerald said, and as of now our focus is in finding a 13-year-old scared girl". Investigators also visited her school, and spoke with her friends, according to the sheriff.
Investigators are working with the National Center for Missing and Exploited Children, and Federal Bureau of Investigation in finding the girl.
"We all have kids", Barron resident Paula Frisinger said.
The sheriff's department says it received a 911 call overnight with one word standing out, "help".
The person who reported it said they saw a black Ford Explorer with possible Wisconsin license plates reading "I60 WER" and two well-dressed men with the girl they believed to be Closs.
The two adults were found dead at the scene. It is believed she may have been taken.
Sheriff Chris Fitzgerald, speaking at a press conference, described Jayme was a sweet and shy girl who enjoys dancing and sports.
Fitzgerald told reporters Tuesday morning that the call was unusual because it came from the home on a cell phone but that the caller did not communicate with the 911 dispatcher.
At 3:20 p.m., an Amber Alert went out on cellphones across western Wisconsin.
Barron County Sheriff Chris Fitzgerald said his office is working with the National Center for Missing and Exploited Children in the search for Jayme Closs.
Fitzgerald says the public is in no immediate danger, that they know of, but there are a lot of unknowns in the case and he couldn't state the public wasn't in any danger.
The sheriff said they are using infrared technology and drones to help in the search.
On Monday afternoon an Amber Alert was issued for Jayme.
It is unknown who made the 911 call.
If you have any information on where Jayme is you're asked to call the sheriff's department at 715-537-3106 immediately.
Barron is about 80 miles (130 kilometers) northeast of Minneapolis.