The baseball Hall of Famer confronted plenty of ugliness as he was pursuing Major League Baseball's home run record in the 1970s, and in an interview with Forbes, he said the criticism Williams has faced - including an Australian newspaper cartoon decried as racist - bears echoes of his own past.
The Herald Sun and the cartoonist denied the accusation, and despite the reactions and outrage it provoked, the paper reprinted the cartoon on Wednesday under the front page headline "WELCOME TO PC WORLD".
The cartoon shows Williams jumping on a broken racket with a baby pacifier.
Mr Knight, who has a reputation for controversial cartoons, was pilloried for his portrayal.
Herald Sun editor Damon Johnston defended Knight and the cartoon saying the cartoon "had nothing to do with gender or race".
Knight's Twitter account appears to no longer be active.
PARIS, FRANCE - MAY 30: Naomi Osaka of Japan celebrates during her ladies singles second round match against Zarina Diyas of Kazhakstan during day four of the 2018 French Open at Roland Garros on May 30, 2018 in Paris, France.
As the International Tennis Federation and Ramos' fellow umpires leapt to his defence, citing the $17,000 in fines that officials levied against Williams as proof of his competency, Simon joined tennis icon Billie Jean King in applauding Williams for bringing officiating hypocrisy to light.
She said: "My favourites are Serena [Williams] and [Roger] Federer".
Since the final some players have spoken publicly and thrown their support behind umpire Carlos Ramos after Williams labeled him a "thief" and a "liar".
Williams later broke her racket and shouted at Ramos, which led to a penalty point and a game penalty.
"I have definitely been thinking about if little kids were watching and they wanted to play tennis too", she said.
Despite the newspaper's recent statement, fans are still labeling the cartoon racist.
Williams' defeat came after she was issued a code violation for receiving coaching, a common practice in the sport.
During a changeover, Williams resumed her argument with the umpire, this time saying he was attacking her character and was a "thief".
Speaking on the eve of Great Britain's Davis Cup match with Uzbekistan in Glasgow, US Open mixed-doubles champion Murray added: "I think the umpire, he did what was within his rights".