But the Swiss champions' artificial pitch will take some getting used to, and was the reason why United left Antonio Valencia behind.
With a reference to Switzerland's greatest sportsman, 20-times Grand Slam victor Roger Federer, Mourinho urged his team to just get on with it.
"Everybody knows it is different. We are in Switzerland, the home of one of the best ever tennis players, and I'm pretty sure the big man sometimes is not happy to play on such a surface but he has to play and he has to win".
"Everybody knows he has a favourite surface but he has also to win on surfaces he is not in love with - so we have to do it". "So we have to do it".
The Red Devils are aiming for a positive result away from home after a hard start to the league season, but are confident after two wins on the bounce.
"It's clear they are not used to pitches like this, so in the beginning I guess it will be a special feeling, but with training and the warm up I think they will be all right".
Mourinho said: "Yes I lost in Switzerland both matches but I won the group phase - a defeat tomorrow and I win the group, I sign immediately". "We've found a certain balance in the team", he added. Mourinho said: "He's selected but I just want to remind you we can only start with 11 so when you see the team you could try to speak about the ones that are going to play and not the ones that are not going to play". "That game was the beginning of our improvement".
Antonio Valencia will not be involved on Wednesday but fellow full-back Luke Shaw is in contention, after recovering from the concussion he suffered on England duty.
"Valencia is the only man who needs protecting from this situation".
For all the optimism over United's recent revival, Mourinho would not be drawn on how he thought his side would do in Europe's elite club competition this season. Now he may have changed - he may be happy playing on the left or the right, or staying at Manchester United.
'I will focus on tomorrow, then a very hard group stage. Our focus must be on qualifying.
'When a team reaches the quarter-finals, even those that aren't considered the favourites, you smell the distance isn't far. "But it's too early".