The more alcohol people drink, the more they are at greater risk of developing conditions such as high blood pressure, heart disease and cancer.
"About 10 million people in England are drinking in ways that increase health risks and many are struggling to cut down".
'Setting yourself a target of having more drink-free days every week is an easy way to drink less and reduce the risks to your health'.
Duncan Selbie, chief executive of Public Health England, told The Times yesterday that enjoying a drink was "absolutely fine" and his advice to take dry days was a tip rather than a target.
While the link with liver disease is well known, many people are not aware that alcohol can cause numerous other serious health problems, such as high blood pressure, heart disease as well as several cancers.
She also pointed out that many people in this demographic were struggling with their weight, and that they didn't realise how many calories were contained in alcohol.
The Drink Free Days campaign will include an app to track how many days they have drunk alcohol and how they compare to the rest of the population.
Drinkaware chief executive Elaine Hindal said: "The more you drink, the greater the risk to your health".
Middle-aged drinkers who often visit the pub after work, have a glass of wine over dinner and consume alcohol while watching sporting events are said to be most at peril. It's really that simple.
'Having a few drink-free days each week will help reduce the risks to your health and improve your wellbeing'.
She said:"Millions of adults in the United Kingdom are drinking in ways that are harmful for their health, often without even realising it".
Middle-aged drinkers are more likely than other age group to drink more than the recommended 14 units a week.
The YouGov poll - by PHE and Drinkaware - surveyed almost 9,000 adults aged 18 to 85 during May and June this year.
The guidance of not exceeding 14 units of alcohol a week comes from the UK's chief medical officer - with a unit equivalent to a single measure of spirits or half a pint of average strength lager, and a 175ml glass of average strength wine equalling two units.
It found that one in five were drinking more than the government's 14 unit-a-week guidelines. Data has been weighted to be representative of the United Kingdom adult population according to gender, age, social grade and region. Most people were not going to stop over health concerns.
Evidence review: this PHE review looks at the impact of alcohol on the public health and the effectiveness of alcohol control policies.
The campaign is part of a growing awareness of the health risks of drinking.