Regular drinking also increases the amount of calories consumed and can contribute to weight gain and obesity.
The campaign encourages people to adopt "a few drink-free days" every week in order to reduce the risk of poor health.
However, a YouGov poll this year has revealed that one in five United Kingdom adults are drinking above the low risk guidelines and more than two thirds of this group say they would find reducing their drinking more hard than improving their diet or exercising more.
He said that drinking should not be treated in the same way as smoking and accepted that alcohol was "a big part of British enjoyment".
Elaine Hindal, chief executive of Drinkaware, said: 'The more you drink, the greater the risk to your health. It's really that simple.
'But an increasing number of people, particularly middle-aged drinkers, are drinking in ways that are putting them at risk of serious and potentially life-limiting conditions such as heart disease, liver disease and some types of cancer.
Public Health England is urging regular drinkers to set a weekly target of non-drinking days to improve health and avoid dependency.
'Having a few drink-free days each week will help reduce the risks to your health and improve your wellbeing'.
Former England and Liverpool footballer John Barnes, 54, is supporting the campaign.
The guidance of not exceeding 14 units of alcohol a week comes from the UK's chief medical officer - with a unit equivalent to a single measure of spirits or half a pint of average strength lager, and a 175ml glass of average strength wine equalling two units.
'But remember, just because you have taken a few days off doesn't mean that you can drink more than usual on the other days'.
The YouGov poll - by PHE and Drinkaware - surveyed almost 9,000 adults aged 18 to 85 during May and June this year. This included a subset of 1,847 adults who drank over 14 units in the last week.
The guidelines also came under fire from the Royal Statistical Society for ruling that even low levels of drinking did not offer men any protective benefit, when experts producing the guidelines had said a unit a day could cut strokes and heart disease.
Evidence review: this PHE review looks at the impact of alcohol on the public health and the effectiveness of alcohol control policies.
The campaign is part of a growing awareness of the health risks of drinking.