On 65, Dortmund were awarded a penalty, and Pulisic made no mistake.
Any hopes that the first goal would help to open up the game proved unfounded, but a string of changes at the interval - which saw Liverpool bring on eight players and Dortmund nine - increased the quality levels on show in Charlotte.
"He has a contract at Dortmund", Klopp said ahead of Sunday's clash with the Bundesliga side. He's a smart player, and unfortunately the US needs more of these players.
"We did our business and Dortmund did theirs".
And America's Sweetheart doubled the excitement among the crowd, scoring the winning goal with minutes remaining - potentially passing his audition for a Liverpool move.
Pulisic is a rising star of world football, and there is no doubt that in the next few years, the United States of America worldwide attacker will establish himself as one of the best players on the planet.
Liverpool came close to doubling their lead but Sheyi Ojo was denied by the crossbar.
It seems Matip is now faced with yet another injury concern, which is sure to come as a blow to Klopp as he continues to gear his Reds side up for the upcoming season. "But he has a really good club now". "I think he'll be fine".
Klopp told a news conference on Saturday: "I like him".
In the past, the Schwarzgelben have been fortunate to call upon the likes of Robert Lewandowski, Pierre-Emerick Aubameyang and even Michy Batshuayi to provide the finishing touch.
The alleged Liverpool target was not done there, though, and he made another break forward in stoppage time before cutting inside and unleashing a shot which Karius could only parry into the path of Larsen, who made no mistake with his rebound despite an attempted last-ditch challenge from Gomez.
Shortly before Liverpool took the lead in the friendly, Karius scuffed a clearance directly to Dortmund forward Maximilian Phillip but the striker wasn't able to punish the error.