Williams wasn't the only former world No.1 casualty on Monday, with rising Russian Daria Kasatkina sending Australian Open champion Caroline Wozniacki crashing out.
Williams' voice shook with dejection and disbelief as she said she can't serve because of a problem with her right pectoral muscle. "Right now I can't actually serve so it's kind of hard to play when I can't physically serve", she said in a press conference Monday morning.
It had been the most eagerly-awaited match of the tournament, coming just two days after Williams had blasted Sharapova's autobiography for being "100 per cent hearsay" when it came to references about her. Fourteen years and eighteen defeats later, Williams is still lauding it over her old rival.
"He deserves respect and he's got nothing to lose in our next match". I just started. So I'm just really trying to get my bearings and trying to feel out where I am and see where I can go.
"When I started to play tennis it was not like this". I can't say I have been intimidated by anyone.
The siblings - one of the finest doubles teams ever - lost 6-0 in the third set to third seeds Andreja Klepac and Maria Jose Martinez Sanchez, with Serena's serve speed visibly declining.
"Physically I'm doing great, it hasn't been easy, I sacrificed so much to be at this event".
Williams replied: "I honestly don't have any thoughts about that".
The sports journalist has since apologized for his condescending "baby" comment and asking if she was intimated by Sharapova because of her "alluring" shoulders.
Kasatkina has reached the quarterfinals for the first time at any major, and she will next play US Open champion Sloane Stephens. "And I'm looking so forward to going up". Informed of NY in two games won against sportswomen from Ukraine Tsurenko, after she withdrew from the tournament with a leg injury.
Muguruza looked dominant in the win over Sharapova, winning in straight sets 6-2, 6-1.
Maria Sharapova's coach says the Russian player was waiting at courtside, ready to go on, when they got the news that Serena Williams was pulling out of their fourth-round match at the French Open. "Because the last years I was always too fast, I was always overpowering my tennis".
The world No. 1's 6-3, 6-2, 7-6 (4) victory over the world No. 70 saw him equal the record of 12 last-eight appearances at Roland Garros, which was set by Novak Djokovic the day before.
"I think Serena hated me for being the skinny kid who beat her, against all odds, at Wimbledon", Sharapova wrote. ".to me, the real answer was there, in this locker room, where I was changing and she was bawling".