The promoted sides were all spared a daunting sequence of games to start the season - although all face one of the "big six" in their opening four matches.
Manchester City's captian, Belgian defender Vincent Kompany (2nd L) and Manchester City's Argentinian striker Sergio Aguero lift up the Premier League trophy on the pitch after the English Premier League football match between Manchester City and Huddersfield Town at the Etihad Stadium in Manchester, north west England, on May 6, 2018.
And the key fixtures remain the first that demand the attention, with the titanic battles between the main title challengers always primed to be pivotal dates in the calendar.
Liverpool host Everton in the first Merseyside derby of the season at the start of December, with the reverse fixture at Goddison Park taking place in early March.
The traditional Premier League 'Clasico' between Liverpool and United is due to be staged at Anfield on December 15, with the return taking place at Old Trafford on February 23.
The Champions League quarterfinal meeting between the two clubs - with both legs won by Liverpool - also intensified the rivalry between the two sides and October's meeting will also be the first time City will travel to Anfield since their team bus was attacked by missile-throwing supporters prior to the Champions League first-leg tie.
Liverpool's start appears more challenging.
Leicester City's first game at King Power Stadium comes a week later on Saturday 18 August, when newly-promoted Wolverhampton Wanderers visit King Power Stadium for the first time since 2013.