The statement referred to Cabello as "the second most powerful man in Venezuela" after Maduro, accusing him of money laundering and involvement in trafficking drugs from Venezuela to Europe. Last year, 125 people were killed in the clashes between government forces and demonstrators, according to Reuters.
The action against Cabello, second-in-command of the ruling United Socialist party, comes just ahead of elections scheduled for Sunday.
In April, Vice President Pence announced that the US would give almost $16 million to United Nations High Commissioner for Refugees to assist Venezuelans, who have fled to Colombia and Brazil.
The U.S. Treasury on Friday imposed sanctions against Cabello, his wife, Marleny Josefina Contreras who heads the country's tourism institute, and his brother, Jose David.
The U.S. slapped sanctions on four Venezuelan nationals and three Florida-based companies on Friday in the latest move meant to put pressure on Caracas.
The three companies, 11420 Corp., Noor Plantation Investments LLC and SAI Advisors Inc. are all based in Boca Raton, Fla. Earlier this month, the United States sanctioned three Venezuelans and 20 firms with alleged ties to Maduro. "The Venezuelan people suffer under corrupt politicians who tighten their grip on power while lining their own pockets", said Secretary of the Treasury Steven Mnuchin, echoing Pence's comments on Friday. The US apparently hopes that additional sanctions will eventually bring about democracy in the South American country, which is suffering from declining oil production, hyperinflation and food shortages.