The squad is headed by Cristiano Ronaldo, who is slated to play in his fourth World Cup.
Forwards Eder and Nani were surprise absentees from Portugal's World Cup squad with national team coach Fernando Santos opting instead for the youth of Andre Silva and Goncalo Guedes to play alongside superstar Cristiano Ronaldo.
Also missing from the 23-man squad were Barcelona duo Andre Gomes, Nelson Semedo, and Renato Sanches who, like Eder and Nani, played at the 2016 European championships won by the Portuguese.
Portuguese coach Fernando Sanches revealed he had to make a hard decision to drop the players that won the Euros two years ago, .
"They have all contributed to writing a brilliant chapter in the history of Portuguese football, but I had to make choices that for me make a better puzzle".
"It hurts not to be able to include all the players who were with us in the European Championship", he said.
Neves in action for Wolves. Image PA
Both started against France in the Euro 2016 final.
He left some high-profile names out of the final 23-man selection that will be travelling to Russian Federation, the biggest being Barcelona duo Andre Gomes and Nelson Semedo. "As a professional, I have to make decisions and I know that I'm not going to please everyone", Santos told a news conference.
"I trust these players the same way I trusted the players who played at Euro 2016".
Portugal are placed in Group B at the World Cup, alongside Iberian neighbour and former World champions Spain, Morocco, and Iran.
Portugal play warm-up matches against Tunisia on May 28, Belgium on June 2 and Algeria on June 7.
Meanwhile, NAIJ.com had earlier reported that France coach Didier Dechamps released his 23-man list where Anthony Martial and Alexandre Lacazette were dropped.