Israel immediately responded at the time with strikes against Syrian air defenses and Iranian "targets", hailing it as "the biggest and most significant attack the air force has conducted against Syrian air defenses" since the 1982 Lebanon War.
The U.K., U.S. and France launched the attacks near Damascus early Saturday.
The Syrian government's staunch allies strongly condemned the overnight airstrikes on Assad regime targets, with Iran's supreme leader branding as "criminals" President Donald Trump, U.K. Prime Minister Theresa May and French President Emmanuel Macron.
Syria's capital has been rocked by loud explosions that lit up the sky with heavy smoke as U.S. President Donald Trump announced airstrikes in retaliation for the country's alleged use of chemical weapons.
Public radio said that Israel had been informed ahead of time of the strikes that were carried out by the United States, France and Britain. "They are crimes of a monster instead", he said.
Netanyahu said Israel would not allow Iran to establish itself in Syria, according to his office.
Iran has been Syrian President Bashar al-Assad's most supportive ally against insurgents throughout the conflict.
Pentagon officials said the attacks targeted the heart of Assad's programs to develop and produce chemical weapons.
"This morning's attack on Syria is a crime".
Iran and Russian Federation have both been close allies of Syria's Assad, with Moscow providing military support for the Syrian government amid a years-long civil war there. All they are waiting for is the flame to ignite the negative backlash against the whole corrupt system of ayatollahs, and they hope that will be supplied by Trump's exit from the nuclear deal.
"He adds ominously, "Hopefully someday we'll get along with Russian Federation, and maybe even Iran, but maybe not".
He stressed that missile strikes at Syria are "justified". Officials also said the strike was larger than a similar attack on the Assad regime launched a year ago.
The Israeli military said the drone was based on the Lockheed Martin RQ-170 Sentinel, which Iran intercepted during what the United States called a reconnaissance mission in December 2011.
Speaking in Washington as the operation was close to concluding, U.S. Defense Secretary James Mattis appeared somewhat at pains to explain what the objective had been, saying it focused on degrading the Syrian government's chemical weapons program only. "Insulting the President of Russian Federation is unacceptable and inadmissible", he added.