It found that hitting a target of limiting global warming to no more than 2C above pre-industrial levels could save half the species at risk.
Half the animals and plants living in the world's most nature-rich areas are at risk of dying out from climate change.
The Galápagos fur seal, albatross and mangrove finch are among the species that could disappear if greenhouse gas emissions rise unchecked, research by the University of East Anglia, James Cook University in Australia and the conservation charity WWF found.
In the report, published on Wednesday in the Climate Change journal, researchers analysed the impact of climate change on nearly 80,000 plant and animal species in 35 of the world's most diverse and naturally wildlife-rich areas.
Giant pandas, snow leopards and polar bears are among the animals that could see their territory and food supplies reduced.
If temperature rises are limited to 2C, which would require further action from governments, the impact on wildlife would be lessened but still wide-ranging.
If there was a 4.5°C global mean temperature rise, the climates in these areas are projected to become unsuitable for numerous plants and animals that now live there meaning up to 90% of amphibians, 86% of birds and 80% of mammals could potentially become locally extinct in the Miombo Woodlands, Southern Africa.
The Amazon could lose 69% of its plant species.
As well as this, increased average temperatures and more erratic rainfall could become the "new normal" according to the report, with significantly less rainfall in the Mediterranean, Madagascar and the Cerrado-Pantanal in Argentina.
Affected wildlife could include turtles, as warmer temperatures lead to more eggs hatching as females or failing to hatch altogether, while rising seas and storms can destroy nesting sites.
"However, if global warming is limited to 2C above pre-industrial levels, this could be reduced to 25%".
The report did not look at the impact of limiting temperature rises to just 1.5C, which countries have pledged to aim for under the global Paris Agreement on climate change, but it would be expected to protect more wildlife, she added.
Dr Stephen Cornelius from WWF-UK said: 'This is a global problem, it shows that across 35 priority places scattered all over the world, all of them over the last 50 years, across all the seasons, have seen temperatures rise.
He warned that plant species are "incredibly vulnerable", with potential knock-on impacts for other species such as birds that might rely for food on a specific plant.