The Russian response was announced on the eve of a presidential election which is expected to hand Vladimir Putin a fourth term in the Kremlin.
Russian Federation today announced it is expelling 23 British diplomats and threatened further retaliatory measures in a growing diplomatic dispute over a nerve agent attack on a former spy in Britain.
Moscow had failed to respond to a deadline set by the Prime Minister to explain how the nerve agent that poisoned former Russian spy Sergei Skripal and his daughter Yulia found its way into Britain.
The Skripals are reported to be in critical condition, but British authorities have provided no further information about their status.
Mr Yakovenko said that Britain had put its weight behind an "anti-Russian campaign" as it tried to establish a new place for itself within Western society after European Union withdrawal.
Russian Federation opens a probe into the "attempted premeditated murder" of Yulia Skripal.
He said Russian Federation "either did not care that the weapon used would be traced back to them, or mistakenly believed they could cover their traces".
British Prime Minister Theresa May said Britain would consider its next steps with its allies in the coming days. "We will never tolerate a threat to the life of British citizens and others on British soil from the Russian Government", she said.
"But Russia's response doesn't change the facts of the matter - the attempted assassination of two people on British soil, for which there is no alternative conclusion other than that the Russian State was culpable".
"No explanation as to how this agent came to be used in the United Kingdom; no explanation as to why Russian Federation has an undeclared chemical weapons programme in contravention of worldwide law".
Russian Federation was slow to respond to May's decision, spending Thursday and Friday promising a swift and strong response.
The Foreign Ministry said it would also order an end to all activities of the British Council, Britain's global organization for cultural relations and educational opportunities, and warned London that "if any further unfriendly actions are taken against Russia, the Russian side reserves the right to take other retaliatory measures".
She said the U.S. would stop complaining about Russia "if the Russian government stopped using chemical weapons to assassinate its enemies, and if the Russian government stopped helping its Syrian allies to use chemical weapons to kill Syrian children".
In comments to reporters after he left the Foreign Ministry, Bristow said the crisis had arisen because of "the attempted murder of two people using a chemical weapon developed in Russian Federation and not declared by Russian Federation".
"The measures are harsh but the British deserved them".
UK Foreign Secretary Boris Johnson upped the stakes Friday when he said it was "overwhelmingly likely" that Russian President Vladimir Putin personally gave the order to use the nerve agent against the Skripals.
Metropolitan Police Assistant Commissioner Neil Basu said: "We are learning more about Sergei and Yulia's movements but we need to be clearer around their exact movements on the morning of the incident".
When asked what Britain should do next, Tom Tugendhat, a Conservative lawmaker and chair of the foreign affairs select committee, told the BBC: "I think what we got to do is focus entirely on the Putin regime, the Putin family and the Putin henchmen, and focus on their money, much of which is hidden in Western Europe".