Cuomo joined CNN in 2013 from ABC News, where he served as anchor of 20/20 and co-hosted Good Morning America, reporting from several worldwide locations.
The move pits Cuomo against MSNBC's Rachel Maddow and Fox powerhouse Sean Hannity who fairly recently moved back to the slot as part of a major shuffle at that cable news network in the wake of Bill O'Reilly's ouster.
Cuomo came over to CNN in 2009 from ABC, where he had stints hosting "Good Morning America" and "20/20".
In January, Cuomo hosted a temporary show "Cuomo Prime Time", although he told The Hollywood Reporter that he had "no ambition" to make the jump to primetime permanently.
CNN is looking to launch "Cuomo Prime Time" in the spring and air it at 9 p.m. EST on weekdays, Variety reports. CNN's 9 a.m. and 10 a.m.co-anchor John Berman will join "New Day" co-host Alisyn Camerota for the early morning shift.
"The show will feature Cuomo's signature in-depth one-on-one interviews that test politicians and newsmakers on their positions, as well as analyses of news of the day and the latest breaking news", CNN added".
In total viewers, Cuomo averaged 1.11 total viewers in prime time and finished 25th overall against its competition. He is the son of former NY governor Mario Cuomo, and the brother of the current governor, Andrew Cuomo.