That's not bothering Roger Federer, who is returning as defending champion just 12 months after entering the season-opening Grand Slam tournament seeded 17th and uncertain of his prospects after six months off the tour with an injured left knee.
Djokovic is in the same quarter as the Zverev brothers - fourth-seeded Alexander could meet older brother and No. 32-seeded Mischa in the third round - 2014 champion Stan Wawrinka, and No. 5 Dominic Thiem.
Her sister Venus, who lost the all-Williams Australian Open final past year, has a tough opener against Belinda Bencic - who combined with Federer to win the Hopman Cup for Switzerland last week - and is also in the same quarter as U.S. Open victor Sloane Stephens.
Top-ranked Simona Halep opens against Australian wild card Destanee Aiava, has a potential second-round match against 2014 Wimbledon finalist Eugenie Bouchard, and is in the same half as Garbine Muruguza, the Wimbledon champion.
The Wimbledon champion is scheduled take on France's Jessika Ponchet in the first round, while French Open champion Jelena Ostapenko was paired with veteran Francesca Schiavone and U.S Open champion Sloane Stephens will take on China's Zhang Shuai.
Australia's sole men's seed, Nick Kyrgios, takes on Brazilian Rogerio Dutra Silva and local women's 18th seed Ashleigh Barty takes on Belarusian Aryna Sabalenka.
In a women's field notably missing 23-time Grand Slam champion Serena Williams, there appear to be many chances of a new Australian Open champion this year.
Players will also be able to claim 50 percent of their prize money if they pull out before their first match, an incentive created to allow a replacement to play instead.
A knee injury which has prevented Nadal from playing competitively since losing to David Goffin at the ATP Finals in November has restricted the 16-time major champion to just a pair of exhibition contests in Melbourne - a far cry from his run to the quarter-finals at the Brisbane International a year ago.
The draw for the January 15-28 tournament, the first grand slam of the year, takes place later on Thursday. Kerber, the only other past champion in the draw, is playing a tournament in Sydney this week.
"I'll be over the moon if I can play", he said.
Australian bad boy Bernard Tomic was fined a third of his £35,000 ($47,500) prize money for unsportsmanlike conduct at Wimbledon, after saying he felt "bored" and "couldn't care less" following a straight-sets defeat on day one.
"Ranking points, player withdrawals and how we deal with that is something we've got to and are looking at", he told Fairfax Media in Auckland.
In a separate rule change created to get matches started more quickly, warm-up times will be strictly enforced.
However, plans for a shot clock to enforce a 25-second time limit between points have been shelved, and will only be used in the qualifying tournament at Melbourne Park. Federer is seeded No. 2 as he bids for a 20th Grand Slam singles title.