The study has identified a pathway to prevent fat cell fat cells from growing larger that leads to weight gain and obesity.
According to the U.S based study published in journal e life, conducted by Washington University in St. Louis U.S; by activating Hedgehog pathway in fat cells in mice- you could feed the animals a high -fat diet without making them overweight.
The researchers managed something for this experiment, known as Hedgehog pathway, which is a signaling system involved in the development of cell throughout the body. the team said that the project succeeded at suppressing the obesity in mice, which represented a feasible pharmaceutical route to the weight condition. Over an eight-week period, a control group of mice fed a high-fat diet predictably became obese, but the mice whose Hedgehog pathway had been activated didn't gain any more weight than another control group fed on a normal diet. While these mice did not balloon on such a diet, the control mice without the special genes did become obese.
"Fat gain is due mainly to increased fat cell size", explains Long. "Each fat cell grows bigger so that it can hold larger fat droplets".
The Hedgehog pathway prevented obesity by inhibiting the size of the fat cells. "We gain weight mainly because fat cells get bigger, as opposed to having more fat cells".
By stimulating Hedgehog and related proteins in fat cells, the researchers kept the animals' fat cells from collecting and storing fat droplets.
Many of us keep the myths and assumptions that we should avoid fats. Senior investigator Fanxin Long said that these findings could help them to a new way of treating obesity. "What's particularly important is that the animals in our study ate a high-fat diet but didn't gain weight, and in people, too much fat in the diet is a common cause of obesity", Long added. People with obesity have an increased risk for stroke, heart attack, diabetes and cancer.