Meanwhile, DeGale will make the fourth defence of his IBF super-middleweight title against Caleb Truax.
James Degale will defend his IBF super-middleweight world title against America's Caleb Truax in his United Kingdom homecoming fight on December 9 in London. Jack was knocked down in the first round but ended strongly flooring the gutsy DeGale in the last round in NY.
Since the draw in New York, DeGale has recovered from shoulder surgery and his return to the United Kingdom coincides with his first appearance on the new BoxNation/BT Sport platform launched by veteran promoter Frank Warren.
"Golden" got his first shot at a World Title when he faced 160-pound Champion Jacobs in Chicago in April 2015.
Truax (28-3-2) has 18 knock-outs from his 28 wins but the 34-year-old has never fought outside his native USA.
With a victory, Selby is hoping to set himself up for a fight with current mandatory challenger and rival Josh Warrington, of England, or one against former titleholder Carl Frampton, of Northern Ireland.
DeGale, 31, unanimously out-pointed Andre Dirrell in Boston for the IBF belt in May 2015 and has since made defences in Quebec, Washington and Brooklyn.
Mexican southpaw Ramirez (20-0-3, 7KOs) is trained by Manuel Montiel Jr, brother of five-time world champion Fernando who Selby beat just over two years ago. He dropped a 10-round decision to the badly faded former undisputed middleweight world champion Taylor in 2012.
"Truax is a good solid fighter with a top pedigree", said DeGale (23-1-1, 14KOs), who is three years younger than his opponent. "He's been in with some quality opponents like Daniel Jacobs, Jermain Taylor and Andre Dirrell".
He'll be fighting away from home so he's going to bring it on and try to take my world title, but I'm the best super middleweight in the world and I'm going into the ring full of confidence and 100 percent fit.
"I've not boxed in London for a few years so I can't wait to make my return to the ring and soak up the atmosphere from the crowd and put on great show for the fans".
"Ramirez is a very good unbeaten fighter and he comes from a good stable", said 30-year-old Selby. Fernando was a former challenger of mine and his brother is a very experienced coach.
"He (Ramirez) has a decent ranking with the IBF and you don't get there by accident, he's worked his way into the mix and he's going to give me a tough test. He's a southpaw which is another challenge for myself".