But on the positive side the study found spending time away from the screen, engaging in social interaction, sports and even doing homework is linked to having fewer depressive symptoms and suicidal tendencies.
The results found that the suicide rate for girls, aged between 13 to 18 years, increased by 65 per cent.
Are you in the habit of spending more time on cellphones, tablets or playing computer games? Those with symptoms of severe depression rose 58 per cent.
"These increases in mental health issues among teens are very alarming", said Jean Twenge, Professor at the San Diego State University in California.
"Teens are telling us they are struggling, and we need to take that very seriously".
The results were based on questionnaires filled out 500,000 U.S. teenagers in two anonymous, nationally representative surveys conducted since 1991.
"When I first saw these sudden increases in mental health issues, I wasn't sure what was causing them", said Twenge. "That was by far not a good formula for mental health", the researchers noted.
Prof Twenge added: "Although we can't say for sure that the growing use of smartphones caused the increase in mental health issues, that was by far the biggest change in teens' lives between 2010 and 2015".
A closer examination of the data revealed a correlation between screen time and suicide-related behaviors. Researchers found almost half of all teens who reported spending more than five hours on electronic devices also reported at least one suicide-related outcome. Only 28 percent of those who spent less than hour looking at screens reported a suicide-related outcome.
The authors surveyed suicide reports between 2009-15 and asked girls about their use of social media, electronic devices, print media, television and how much time they spent with friends.
Researchers published their findings this week in the journal Clinical Psychological Science.
Previous studies have shown links between time spent of social media and depression among teens.